csp-1 — Neurospora crassa

Summary

NCU02713, symbol csp-1 on Neurospora crassa chromosome 1, encodes a C2H2-type zinc-finger protein with DNA-binding transcription repressor activity and RNA polymerase II-specific activity. The gene is associated with glucose homeostasis, negative regulation of transcription by RNA polymerase II in response to glucose, and regulation of carbon utilization. It is linked to circadian rhythm, glycogen metabolism, negative regulation of isoprenoid metabolism, quorum sensing, filamentous growth, chlamydospore formation, and development of symbiont in host. The protein localizes to the nucleus, cytoplasm, chromatin, transcription regulator complex, and PcG protein complex. Studies of related genes in other species link the family to altered virulence, including both hypervirulence and reduced virulence, as well as associations with invasive candidiasis and diseases of crops such as maize ear rot and peanut yellow mold.