DLH1 — Neurospora crassa

Summary

NCU02741 (DLH1, mei-3) on Neurospora crassa chromosome 1 encodes a RecA-family recombinase with ATPase, DNA-binding and recombinase activity, and is a member of the Rad51/DMC1 protein family. The gene is associated with meiotic strand invasion, heteroduplex formation, joint molecule formation, gene conversion, and double-strand break repair during meiotic recombination, as well as mitotic recombination-dependent replication fork processing, stalled replication fork localization, and mitochondrial DNA repair. It localizes to condensed nuclear chromosomes, mitochondrial chromosomes, centromere complexes, sites of double-strand breaks, and the nuclear envelope. Phenotypic associations include absent X-ray resistance, absent mitotic recombination, absent sporulation efficiency, abnormal spore germination, delayed chromosome segregation, and altered cell cycle progression through G1/S and metaphase-anaphase transitions. Related genes in other species link the family to meiotic recombination.