pep — Neurospora crassa

Summary

NCU02549 (pep, also known as COR1, QCR1, NcQCR1, or NcCOR1) on Neurospora crassa chromosome 1 encodes a protein with metalloendopeptidase activity (EC 3.4.24.64) and is associated with signal peptidase, endopeptidase activator, quinol-cytochrome-c reductase, and structural molecule activities. The gene is associated with mitochondrial protein processing, import, and electron transport, as well as aerobic respiration, cellular respiration, proton transmembrane transport, regeneration, and sporulation. It localizes to the mitochondrial inner membrane and lumen. Phenotypic associations include delayed respiratory growth, decreased oxidative phosphorylation, increased mitochondrial genome maintenance, premature cell cycle progression, abnormal meiosis, decreased apoptosis, and absent desiccation resistance. Related genes in other species link the family to respiratory complex III assembly and function.