camk-2 — Neurospora crassa

Summary

NCU02283, designated camk-2 on Neurospora crassa chromosome 7, encodes a protein with calcium/calmodulin-dependent kinase activity, protein kinase A activity, calmodulin binding, protein serine/threonine kinase activity, and ATP binding. The gene is associated with the CAMKK-AMPK signaling cascade, negative regulation of calcineurin-mediated signaling, and cellular response to calcium ions. It is linked to regulation of invasive growth in response to glucose limitation, positive regulation of pseudohyphal growth, upregulation of gluconeogenesis and macroautophagy, and downregulation of protein localisation to nucleus. Additional associations include fungal-type cell wall assembly, single-species surface biofilm formation, mycose catabolism, meiotic G2/MI DNA replication checkpoint, mitotic DNA damage checkpoint, and S-M checkpoint. The protein localises to the ascus epiplasm, perinuclear space, ascospore-type prospore, nucleotide-activated protein kinase complex, division septum, and cell cortex.