for — Neurospora crassa

Summary

NCU02274, also known as for, SHM1 or SHM2 on Neurospora crassa chromosome 7, encodes a serine hydroxymethyltransferase with glycine hydroxymethyltransferase activity and pyridoxal phosphate binding, placing it in the Ser_HO-MeTrfase-like family. This enzyme is associated with tetrahydrofolate interconversion, one-carbon metabolism, methylation, and melanin anabolism, and localises to mitochondria, cytoplasm, and the fungal biofilm matrix. The gene is linked to hyphal growth, digestion, nuclear export, and responses to amino acids and histidine. Phenotypic associations include arrested meiosis, decreased S-phase progression, absent respiratory metabolism, abnormal plasma membrane morphology, increased meiotic recombination, decreased colony size, and altered budding patterns. Studies of related genes in other species connect the family to nutrient utilization and turgor pressure.