ERG5 — Neurospora crassa

Summary

NCU02031 (ERG5) on Neurospora crassa chromosome 1 encodes a cytochrome P450 with long-chain fatty acid omega-hydroxylase activity, heme and iron binding, and oxidoreductase activity acting on paired donors with oxygen incorporation. The gene is associated with ergosterol, terpenoid, hormone, antibiotic and mycotoxin anabolism, and hypersensitivity. It localises to the membrane. ERG5 is associated with increased fermentative growth, decreased endocytosis, absent micronucleophagy, abnormal telomere length and plasma membrane morphology, absent vacuolar transport, decreased meiosis, abnormal autophagy, decreased shmoo formation, increased budding, absent protein secretion, decreased colony size, increased small molecule transport, arrested M phase and delayed G2/M cell cycle progression, decreased cytokinesis, increased cell death, abnormal cytoskeleton morphology, decreased nutrient uptake, abnormal mitochondrial distribution and peroxisomal morphology, decreased mating response, arrested vegetative growth, decreased apoptosis, decreased mitochondrial genome maintenance, and petite phenotype. Related genes in other species link the family to potassium concentration and acid sensitivity.