SOD1 — Neurospora crassa

Summary

NCU02133 (SOD1, sod-1) on Neurospora crassa chromosome 1 encodes a copper-zinc superoxide dismutase with superoxide dismutase activity, copper binding, and oxidoreductase activity acting on sulphur group donors with oxygen as acceptor. The gene is associated with cell redox homeostasis, removal of O2-, copper ion transport and homeostasis, cellular zinc ion homeostasis, calcium signaling, signal transduction, positive regulation of transcription by RNA polymerase II, photomorphogenesis, inhibition of oxidative metabolism, lignin breakdown, carotenoid anabolism, sphingolipid anabolism, protein stabilization, and fungal-type cell wall organization. The product localizes to the cytoplasm, cytosol, nucleus, and mitochondrial envelope lumen. Phenotypic associations include altered oxidative stress resistance, desiccation resistance, spore germination, cell cycle progression, fermentative growth, mitochondrial genome maintenance, vacuolar distribution, pexophagy, necrotic cell death, and nuclear export. Related genes in other species link SOD1 to oxidative stress response and protein content.