SRBA — Neurospora crassa

Summary

NCU01871 (SRBA) on Neurospora crassa chromosome 1 encodes a bHLH domain-containing protein with DNA-binding transcription activator activity, protein dimerization activity, and SRE binding. The gene is associated with sterol and steroid metabolism, regulation of ergosterol biosynthetic process, and sterol homeostasis. It is linked to SREBP signalling, cellular response to hypoxia, copper, and neutral pH, as well as carbon catabolite activation of transcription. SRBA is associated with upregulation of glycolysis, filamentous growth, and biofilm formation, and with biological process involved in symbiotic interaction. The protein localises to the Sre1-Scp1 complex, endoplasmic reticulum membrane, nuclear envelope, Golgi membrane, chromatin, cytoplasm, and nucleus. Studies of related genes in other species link the family to reduced virulence and associations with pulmonary aspergillosis and disseminated candidiasis.