SSK1 — Neurospora crassa

Summary

NCU01895 (SSK1, rrg-1) on Neurospora crassa chromosome 1 encodes a protein with 2C_system_His_kinase and CheY-like superfamily domains, and has phosphorelay sensor kinase activity, protein kinase activator activity, phosphorelay response regulator activity, and ATP binding. The gene is associated with regulation of sporulation, regulation of cellular response to oxidative stress, regulation of filamentous growth of a population of unicellular organisms, conidiophore development, germ tube formation, tube formation, osmolarity sensing via two-component system, activation of p38 cascade, upregulation of filamentous growth of a population of unicellular organisms in response to neutral pH, histidyl-aspartyl phosphorelay, flocculation, osmotic response, immune evasion, negative regulation of mitotic entry, cellular response to neutral pH, filamentous growth of a population of unicellular organisms in response to neutral pH, upregulation of filamentous growth of a population of unicellular organisms in response to starvation, and MAPK cascade. The product localises to the Mcs4 RR-MAPKKK complex, cell tip, cell division site, cytoplasm, and cytosol. SSK1 is also associated with oxidative stress response. Studies of related genes in other species link the family to increased virulence, loss of pathogenicity, reduced virulence, and germination rate.