AOX1 — Neurospora crassa

Summary

NCU01853, also known as AOX1, encodes a choline dehydrogenase belonging to the GMC oxidoreductase family, with alcohol oxidase and pyranose dehydrogenase (acceptor) activities, acting on CH-OH group donors and binding FAD or FADH2. This gene is associated with methane breakdown, methanol metabolism, and fermentation, and its product localises to the peroxisomal lumen and extracellular space. Studies of related genes in other species link the family to reduced virulence, though these associations are not yet established in Neurospora crassa.