nit — Neurospora crassa

Summary

NCU01838 (symbol nit) on Neurospora crassa chromosome 2 encodes a protein with arylacetonitrilase (EC 3.5.5.1) and aminoacyl-tRNA ligase activities, belonging to the nitrilase and C-N hydrolase families. The gene is associated with nitrate assimilation and its regulation, nitrogen utilization, nitrate import, nitrogen catabolite repression, and glutamine metabolism. It is also linked to siroheme and molybdenum cofactor biosynthesis, tRNA thiolation, purine base transport, amino acid breakdown, electron transfer, nuclear transport, and DNA-mediated transformation. Traits connected to NCU01838 include nitrate transport and uptake, as well as nitrogen and molybdenum content. Studies of related genes in other species link the family to altered autophagy, mitophagy, heat sensitivity, chronological lifespan, hyperosmotic stress resistance, vegetative growth rate, competitive fitness, and chemical resistance.