CYS3 — Neurospora crassa

Summary

NCU01652 (CYS3) on Neurospora crassa chromosome 2 encodes an O-acetylhomoserine aminocarboxypropyltransferase, a pyridoxal phosphate-dependent enzyme with O-acetylhomoserine (thiol)-lyase and cysteine-S-conjugate β-lyase activities. The gene is associated with L-homocysteine and L-methionine biosynthesis, transsulfuration, cysteine anabolism, sulfur metabolism, and alkaloid metabolism. It is linked to sulphate transport, cell growth, and localisation to the cytoplasm, cytosol, nucleus, and peroxisome. Phenotypic associations include abnormal nutrient utilization and sulfur source utilization, altered cell cycle progression through G2/M and G1 checkpoints, increased UV and X-ray resistance, increased aneuploidy and meiotic recombination, decreased prion inheritance, absent filamentous growth, and altered mitophagy and nucleophagy. Studies of related genes in other species link the family to oxidative stress response and, in maize, to ear and stalk rot.