PMA1 — Neurospora crassa

Summary

NCU01680 (PMA1, pma-1) on Neurospora crassa chromosome 2 encodes a P-type ATPase IIIA family protein (EC 7.1.2.1) with proton-transporting ATPase activity, ATP binding, and calcium and manganese ion binding. It is associated with proton export across the plasma membrane, cellular pH regulation, calcium and manganese ion transport and homeostasis, macroautophagy, protein folding, and structural organization. The protein localizes to the plasma membrane, ER, Golgi, lipid rafts, extracellular vesicles, cell tips, and division sites. Phenotypic associations include abnormal spore germination, delayed sporulation and meiosis, altered replicative lifespan, absent hyperosmotic stress resistance, increased nutrient uptake, and abnormal plasma membrane morphology, shmoo formation, and vesicle distribution. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.