ham-5 — Neurospora crassa

Summary

NCU01789, designated ham-5 on Neurospora crassa chromosome 2, encodes a protein with transcription coactivator activity and RNA binding, containing TPR_GEMI5, PGC-1, and WD40 repeat domains. The gene is associated with the nucleus and linked to diverse biological processes including cell-cell fusion, membrane fusion, myoblast fusion, macrophage fusion, chemotropism, MAPK cascade, signal transduction, energy homeostasis, placentation, cellular localization, cell communication, and positive regulation of transcription by RNA polymerase II. Studies of related genes in other species connect the family to fungal pathogenesis, though this is not established for N. crassa.