ARG3 — Neurospora crassa

Summary

NCU01667 (ARG3, NcARG3) on Neurospora crassa chromosome 2 encodes a protein with ornithine carbamoyltransferase, aspartate carbamoyltransferase, carbamoyl-phosphate synthase (ammonia and glutamine-hydrolyzing), and glutaminase activities, along with amino acid, ATP, and metal binding. The protein localizes to mitochondria, cytoplasm, cytosol, and nucleus. ARG3 is associated with the urea cycle, citrulline biosynthesis, glutamine metabolism, de novo UMP and pyrimidine biosynthesis, histidine biosynthesis, amino acid metabolism, and protein synthesis. Phenotypic associations link the gene to increased lifespan, altered cell death rate, increased freeze-thaw resistance, decreased pexophagy and reticulophagy, increased mitophagy, increased sporulation efficiency, decreased fermentative growth, abnormal mitochondrial transport and distribution, decreased mitochondrial genome maintenance, delayed G1/S cell cycle progression, increased carbon source utilization, absent nitrogen source utilization, decreased acquired thermotolerance, and decreased survival in stationary phase. Studies of related genes in other species connect the family to abnormal vegetative growth and colony appearance.