gla-1 — Neurospora crassa

Summary

NCU01517 (gla-1) on Neurospora crassa chromosome 2 encodes a glucoamylase, with a glucoamylase active site, starch-binding domain (CBM20), and GH15-like fold. The enzyme possesses glucoamylase activity (EC 3.2.1.3) and O-glucosyl hydrolase activity, and is annotated for starch binding. The gene is associated with glycogenolysis, polysaccharide breakdown and metabolism, carbon catabolite repression, secretion, and the meiotic cell cycle. The product localizes to the extracellular space, fungal-type vacuole, Golgi complex, endoplasmic reticulum, and cell-bound fraction. Related genes in other species link the family to polysaccharide degradation in pathogenic fungi.