CLR3 — Neurospora crassa

Summary

NCU01525 (CLR3, hda-1) of Neurospora crassa on chromosome 2 encodes a histone deacetylase with activity on histones H3 and H4, including H3-K9, H3-K14, H4-K12, H4-K16, and H4-K5/K8. The product belongs to the Arb2 domain and class II histone deacetylase families. CLR3 is associated with chromatin silencing, including heterochromatin island and rDNA heterochromatin assembly, centromeric and telomeric silencing, and epigenetic downregulation of gene expression. It is linked to replication fork arrest, cellular response to basic pH, and regulation of phenotypic switching. The gene is associated with increased rates of sporulation, fermentative growth, and carbon source utilization, as well as abnormal mating-type switching, pheromone production, and mitotic recombination. CLR3 also associates with increased freeze-thaw resistance, absent desiccation resistance, and delayed mitophagy. The protein localizes to HDAC complexes including Rpd3S, SET3C, and euchromatin.