YPT3 — Neurospora crassa

Summary

NCU01523 (YPT3) on Neurospora crassa chromosome 2 encodes a small GTP-binding protein of the Rab family, with GTPase activity and GTP binding. The gene is associated with regulation of vesicle-mediated transport, exocytosis, protein secretion, and membrane addition at sites of cytokinesis. It has been linked to mitotic and meiotic cell cycle progression, sporulation efficiency, vegetative growth, and cell death. Localisation evidence connects the product to the Spitzenkörper, recycling endosome, cleavage furrow leading edge, and growing cell tip. Phenotypic associations include delayed cell cycle progression, abnormal Golgi morphology, increased polyploidy and aneuploidy, decreased cell fusion, and altered nutrient uptake. Related genes in other species link the family to endosome-to-plasma membrane transport and vacuole organisation.