PRO1 — Neurospora crassa

Summary

NCU01412 (PRO1) on Neurospora crassa chromosome 5 encodes a protein with glutamylphosphate reductase activity (EC 1.2.1.41) and contains aldehyde dehydrogenase and NADP-binding domains. The gene is associated with L-proline biosynthetic process, histogenesis, syngamy, mating, MAPK cascade, and pigment accumulation, and its product localises to the cytosol. PRO1 is associated with numerous phenotypes including abnormal colony colour, increased cell death, altered stress resistance (increased oxidative stress resistance but decreased UV, acid, desiccation, and thermotolerance), increased invasive growth, decreased respiratory growth, auxotrophy, and altered carbon and nitrogen source utilisation. Studies of related genes in other species link the family to decreased cold sensitivity, decreased replicative lifespan, and abnormal vacuolar morphology.