BTS1 — Neurospora crassa

Summary

NCU01427 (BTS1, al-3) on Neurospora crassa chromosome 5 encodes a polyprenyl synthetase with geranyltranstransferase, farnesyltranstransferase, dimethylallyltransferase and copalyl diphosphate synthase activities (EC 2.5.1.10, 2.5.1.1, 2.5.1.29). The gene is associated with isoprenoid, carotenoid, geranylgeranyl diphosphate, farnesyl diphosphate and geranyl diphosphate anabolism, as well as phototropism, blue light response, pigmentation, asexual sporulation, carbon catabolite repression, developmental process, amino acid transport and protein phosphorylation. The product localises to the cytoplasm. Phenotypic associations include decreased pheromone sensitivity and mating efficiency, altered cell cycle progression (G1/S and G2/M transitions), abnormal peroxisomal and endomembrane morphology, absent autophagy and cell death, increased biofilm formation and acid pH resistance, and decreased invasive and pseudohyphal growth. Related genes in other species include ERG20 and BTS1.