HAM1 — Neurospora crassa

Summary

NCU01441, designated NcHAM1 on Neurospora crassa chromosome 5, encodes an ITP diphosphatase (EC 3.6.1.66) belonging to the RdgB/HAM1 ITPase-like family. The enzyme exhibits XTPase, ITP diphosphatase, and dITP diphosphatase activities, and is associated with nucleotide binding and metal binding. NcHAM1 localises to both the cytoplasm and nucleus, and is linked to deoxyribonucleoside triphosphate breakdown, nucleoside triphosphate breakdown, protein palmitoylation, nucleotide metabolism, sexual reproduction, and mating. The gene is associated with numerous phenotypes including abnormal colony colour and chemical compound excretion, decreased colony size and spore germination, increased pseudohyphal and filamentous growth, increased osmotic stress resistance, decreased mutation frequency, decreased alkaline pH resistance, decreased telomere length, increased chronological lifespan, and abnormal cell cycle progression including S phase abnormalities and G2/M phase arrest.