RAS1 — Neurospora crassa

Summary

NCU01444 (RAS1) on Neurospora crassa chromosome 5 encodes a small GTPase of the Ras-type family, possessing GTP and GDP binding, GTPase activity, and protein serine/threonine kinase activator activity. It is associated with Ras protein signal transduction, the cAMP/PKA signaling cassette, and upregulation of TORC1 signaling. The gene is linked to negative regulation of asexual sporulation, regulation of conidium formation, cell-abiotic substrate adhesion, biofilm formation, cellular response to glucose stimulus, and activation of L-arginine uptake. Localisation evidence places the product at the plasma membrane, endomembrane system, cytosol, and nucleus. Phenotypic associations include decreased vacuolar transport rate, absent bipolar budding, increased mating type switching, decreased rate of entry into G0, absent osmotic and oxidative stress resistance, decreased flocculation, and delayed nuclear export. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.