DBP2 — Neurospora crassa

Summary

NcDBP2 (NCU01369) on Neurospora crassa chromosome 5 encodes a DEAD-box RNA helicase with ATP hydrolase activity, translation initiation factor activity, and mRNA/RNA binding. It is associated with RNA splicing, mRNA processing, ribosome biogenesis, cytoplasmic translational initiation, and negative regulation of cytoplasmic translational initiation in response to stress, as well as RNA-dependent gene silencing and fruiting body formation. The protein localises to the cytoplasm, nucleus, and spliceosome complex. Phenotypic associations link NcDBP2 to abnormal mitotic recombination, decreased mating type switching, absent sporulation efficiency, delayed vegetative and exponential growth, increased thermotolerance and gamma ray resistance, altered cell cycle progression (including increased S phase rate, premature G1/S transition, delayed anaphase, and G2 phase duration changes), increased fermentative growth, and altered carbon source utilisation. Related genes in other species are linked to oxidative stress response.