CPCC — Neurospora crassa

Summary

NCU01187 (CPCC, cpc-3) on Neurospora crassa chromosome 5 encodes a protein with eukaryotic translation initiation factor 2alpha kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, ATP binding, and tRNA binding, and belongs to the HisRS-related and protein kinase domain families. The gene is associated with downregulation of translation initiation in response to stress, response to amino acid starvation, positive regulation of autophagy, and regulation of the MAPK cascade. It is linked to cell cycle progression, including G1/G0 transition, mitotic cytokinesis, and meiotic spindle pole body organization, and localizes to the actomyosin contractile ring, spindle microtubules, and Cdc42 GTPase complex. Phenotypic associations include altered virulence, spore germination, cell death, replicative lifespan, and resistance to UV, desiccation, and freeze-thaw stress, as well as abnormal mating projection morphology and nuclear fusion during mating. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.