IMP1 — Neurospora crassa

Summary

NCU01249 (IMP1, NcIMP1) on Neurospora crassa chromosome 5 encodes an importin-alpha family protein with an importin-alpha IBB domain and ARM-type fold, functioning as a nuclear import signal receptor with NLS-binding, identical protein binding, and GTP-binding activities. The gene is associated with NLS-dependent protein nuclear import, mitotic nuclear pore complex disassembly, regulation of mitotic nuclear envelope breakdown, and protein localization to membrane rafts. It is linked to NVJ assembly, lipophagy, ribophagy, pexophagy, vacuole inheritance, homotypic vacuole fusion, and ergothioneine anabolism. Localization evidence connects the product to the NLS-dependent protein nuclear import complex, Myo2p-Vac17p-Vac8p transport complex, NVJ, lipid rafts, PAS, nuclear periphery, nucleoplasm, nuclear membrane, nuclear envelope, and fungal-type vacuole membrane. Phenotypic associations include abnormal cell cycle progression, delayed cytokinesis, increased sporulation, decreased endocytosis, increased hydrostatic pressure resistance, and abnormal chronological lifespan.