CUP5 — Neurospora crassa

Summary

NCU01332 (CUP5, vma-3) on Neurospora crassa chromosome 5 encodes a proteolipid subunit of the V-type ATPase V0 domain, with proton-transporting ATPase activity and ATP hydrolase activity. The gene is associated with vacuolar acidification, vacuole organization, proton transmembrane transport, endocytosis, vacuolar protein sorting, and cellular copper and iron ion homeostasis, as well as NO storage. It localizes to the vacuolar membrane, fungal-type vacuole, and endoplasmic reticulum. Phenotypic associations include decreased cell cycle progression, increased entry into G0, increased fermentative growth, increased nutrient uptake, increased hydrostatic pressure and freeze-thaw resistance, absent hyperosmotic stress resistance, abnormal replicative lifespan, and sterility. Studies of related genes in other species link the family to vacuolar transport, pheromone response, and stress resistance.