rpd — Neurospora crassa

Summary

NCU01270, symbol rpd (also known as PRS5 or NcPRS5) on Neurospora crassa chromosome 5, encodes a protein with ribose phosphate diphosphokinase activity, kinase activity, ATP binding and magnesium binding. The product is a member of the PRTase-like and Pribosyltran_N domain families and localises to the cytoplasm, cytosol, nucleus and PRPP synthetase complex. The gene is associated with PRPP biosynthetic process, ribonucleoside monophosphate and purine nucleotide anabolism, cell size control, and methylation. Phenotypic associations include decreased budding and cell size, increased aneuploidy and prion formation, abnormal cell cycle progression with increased G1 phase duration, abnormal nuclear and ER morphology, altered filamentous growth, absent or decreased sporulation, decreased telomere length, and altered killer toxin resistance. Studies of related genes in other species link the gene to ribose-phosphate pyrophosphokinase function (EC 2.7.6.1).