SET1 — Neurospora crassa

Summary

NCU01206, the Neurospora crassa gene set-1 (SET1) on chromosome 5, encodes a histone H3K4 trimethylase (EC 2.1.1.354) and also possesses RNA-binding activity. The product is a Set1-family protein that assembles into the Set1C complex and localises to chromosomes, and is associated with methylation and chromatin modelling. The gene is associated with a wide range of cell-cycle phenotypes, including altered progression through G2/M and metaphase-anaphase transitions, premature meiosis, and increased sporulation and transposable-element transposition. It is also linked to abnormal pheromone production and sensitivity, delayed exit from stationary phase, and changes in RNA and protein accumulation. Studies of related genes in other species connect the family to the COMPASS complex and to interactions with regulators such as Set3C and Rec114.