SOD2 — Neurospora crassa

Summary

NCU01213 (sod-2, SOD2) on Neurospora crassa chromosome 5 encodes a Mn/Fe superoxide dismutase (EC 1.15.1.1) with superoxide dismutase activity, Mn binding, and IgE binding. The gene is associated with removal of O2-, evasion or tolerance of host-produced AOS, innate immunity, excretion, and secretion. The product localises to the mitochondrial lumen, mitochondria, and cytosol. Associations include photosynthetic rate, and numerous phenotypes such as increased necrotic cell death, abnormal respiratory metabolism, increased hydrostatic pressure and freeze-thaw resistance, decreased radiation and pheromone sensitivity, abnormal spore wall and septum formation, altered cell cycle progression, and changes in fermentative growth and metabolism. Studies of related superoxide dismutase genes in other species link the family to oxidative stress response, sodium concentration, manganese content, and salt tolerance.