CLM2 — Neurospora crassa

Summary

NCU01134 (CLM2) in Neurospora crassa encodes a cytochrome P450 monooxygenase with heme and iron binding, classified in the fungal cytochrome P450 family and exhibiting tryptamine 4-monooxygenase activity. The gene is associated with ergosterol, sterol, terpenoid, phospholipid, ceramide, and psilocybin biosynthetic processes, as well as sterol homeostasis and hypersensitivity. Its product localises to membranes. Phenotypic associations include decreased micronucleophagy, nucleophagy, and ribophagy; increased cell death and cell cycle progression through G2/M; abnormal G0 entry and S phase progression; absent cytokinesis, hyperosmotic stress resistance, and vegetative growth arrest; decreased invasive growth, shmoo formation, and nutrient uptake; increased fermentative metabolism and lifespan; and abnormal plasma membrane morphology and endoplasmic reticulum distribution. Studies of related genes in other species link the family to ergosterol biosynthesis, while sequence similarity connects it to sterol 14α-demethylase and protein content traits.