mcb — Neurospora crassa

Summary

NCU01166 (mcb) of Neurospora crassa encodes a regulatory subunit of cAMP-dependent protein kinase A, containing a cAMP-binding domain and a cAMP-dependent protein kinase regulatory chain. The gene product is associated with cAMP metabolism, signal transduction, and the cAMP-dependent protein kinase complex, localizing to both the cytosol and nucleus. It is linked to the positive regulation of asexual sporulation, carbon catabolite repression, sexual reproduction, hyphal growth, morphogenesis, protein secretion, and cellular responses to stress and oxidative stress. Phenotypic associations include decreased spore germination, increased virulence, abnormal cell cycle progression, altered fermentative growth, and abnormal chromosome segregation. Studies of related genes in other species link the family to reduced virulence and loss of pathogenicity.