CWC25 — Neurospora crassa

Summary

NCU00901, also known as CWC25 or uvs-6 in Neurospora crassa on chromosome 1, encodes a protein with DNA helicase and ATP hydrolase activities that binds ATP, metal ions, and various DNA forms including double-stranded telomeric DNA, single-stranded telomeric DNA, and G-DNA. The protein belongs to the Rad50/SbcC_AAA and Zn_hook_RAD50 domain families. It is associated with the MRN complex and localizes to condensed nuclear chromosomes, chromatin, and sites of double-strand breaks. The gene is linked to numerous DNA repair and recombination processes, including double-strand break repair via homologous recombination and non-homologous end joining, meiotic recombination and chromosome organization, telomere maintenance through both telomerase and recombination pathways, replication fork processing, and the intra-S DNA damage checkpoint. Related genes in other species further connect this gene to DNA repair mechanisms.