HOB3 — Neurospora crassa

Summary

NCU01069 (HOB3) in Neurospora crassa encodes the amphiphysin-like protein amph-1, which contains a BAR domain and is classified as a cytoskeletal protein-binding and membrane-anchor adaptor with lipid-binding, calmodulin-binding and identical protein-binding activities. The gene is associated with plasma membrane and lipid tubulation, cell-cell fusion, regulation of endocytosis, actin cytoskeleton organization, mitotic contractile ring assembly, division septum assembly, cell polarity establishment, filamentous growth, osmotic response, response to starvation, and mitochondrial biogenesis. The product localizes to the actin cytoskeleton, lipid rafts, cellular bud tips, mating projection tips, and the Rvs161p-Rvs167p complex. Phenotypic associations link HOB3 to absent cell fusion, delayed nuclear fusion during mating, decreased cytokinesis rate, abnormal filamentous growth, increased adhesion, altered carbon and nitrogen source utilization, and abnormal prion inheritance.