DBP2 — Neurospora crassa

Summary

NCU01104 (DBP2) on Neurospora crassa chromosome 5 encodes an ATP-dependent RNA helicase of the DEAD/DEAH-box family, with RNA helicase, G-quadruplex binding, RNA strand annealing, and ATP hydrolase activities. The gene is associated with mitochondrial RNA processing, including group I and group II intron splicing, snoRNA release from pre-rRNA, and mitochondrial transcription and translation processes. It is linked to ribosome biogenesis, rRNA maturation, and mRNA processing, and localises to mitochondria, the nucleolus, and the nuclear envelope. Phenotype associations include abnormal mitotic recombination, decreased mating-type switching, absent sporulation efficiency, increased thermotolerance and gamma ray resistance, delayed vegetative growth, and altered cell cycle progression through G1/S and G2/M transitions. Studies of related genes in other species link the family to oxidative stress response.