csr-1 — Neurospora crassa

Summary

NCU00726, designated csr-1 on Neurospora crassa chromosome 1, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) that binds cyclosporin A and exhibits cis-trans proline isomerase and RNA-binding activities. The protein localises to the endoplasmic reticulum lumen, cytoplasm, nucleus, mitochondria, vacuole, yeast-form cell wall and fungal biofilm matrix. csr-1 is associated with bioluminescence, homologous recombination, protein folding and mating. Studies of related genes in other species, including cyp1, cyp2 and cyp9, link the family to additional cellular processes, though these associations are not yet established for csr-1 itself.