CSN2 — Neurospora crassa

Summary

NCU00593 (CSN2, csn-2) on Neurospora crassa chromosome 1 encodes a PCI-domain protein with structural molecule activity and inositol hexakisphosphate (IP6) binding. It is a component of the COP9 signalosome and the proteasome regulatory particle lid subcomplex, localising to the cytoplasm, cytosol and nucleus. The gene is associated with protein deneddylation, proteasomal protein catabolic processes, ubiquitin-dependent proteolysis, and the DNA damage response. It is also associated with circadian rhythm and cleistothecium development. Related genes in other species, including Fusarium and Verticillium species, are linked to the CSN2 family.