ARG5 — Neurospora crassa

Summary

NCU00567 (ARG5, also known as arg-6) on Neurospora crassa chromosome 1 encodes a protein with acetylglutamate kinase activity (EC 2.7.2.8) and N-acetyl-gamma-glutamyl-phosphate reductase activity (EC 1.2.1.38), and binds ATP, NAD, and NADP+. The protein localises to the mitochondrial lumen and is associated with ornithine and arginine biosynthesis and the urea cycle. It is also linked to regulation of DNA-templated transcription. Phenotypic associations include decreased filamentous and invasive growth, increased stress resistance and thermotolerance, altered mitochondrial transport and genome maintenance, reduced mitophagy and pexophagy, increased mutation frequency, and changes in nutrient uptake, cell size, and lifespan. Studies of related genes in other species link the family to nitrogen source utilisation, endocytosis, auxotrophy, and toxin resistance.