CP1 — Neurospora crassa

Summary

NcCP1 (NCU00477) on chromosome 3 of Neurospora crassa encodes a serine carboxypeptidase (EC 3.4.16.5) belonging to the peptidase S10 and AB hydrolase families, with a propeptide carboxypeptidase Y domain. The gene is associated with proteolysis, chromatin silencing, nucleosome organization, mitosis, mating, DNA damage response, methylation, and memory. It is linked to fungal-type vacuole lumen localization. Phenotypic associations include abnormal autophagy, increased or decreased cell death, altered prion inheritance, abnormal nuclear fusion during mating, increased aneuploidy, decreased mitophagy and pexophagy, abnormal protein secretion, and increased lifespan. The gene is also associated with X chromosome inactivation, ectoderm development, and entry into G0 stationary phase. Studies of related carboxypeptidase Y family members in other species link the family to apoplastic effector function and floral organ identity.