gnb-1 — Neurospora crassa

Summary

NCU00440 (gnb-1) on Neurospora crassa chromosome 3 encodes a G-protein beta subunit containing WD40 repeats, with signaling receptor complex adaptor activity, DNA-binding transcription repressor activity, mediator complex binding, histone deacetylase binding, PtdIns(3,5)P2 binding, ubiquitin ligase substrate adaptor activity, transcription corepressor activity, histone binding, and GTP binding. The gene is associated with GPCR signaling, cAMP metabolism, regulation of adenylyl cyclase activity, glucose-sensing PKA pathway, negative regulation of isoprenoid metabolism, syngamy, quorum sensing, phenotypic switching, filamentous growth regulation, HOG response, cellular response to copper, mitigation of host defenses by symbiont, and development of symbiont in host. The product localizes to heterotrimeric G-protein complex, transcription repressor complex, SCF complex, chromatin, and cytoplasm. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.