ERF1 — Neurospora crassa

Summary

NCU00410, designated NcERF1 (also known as SUP45) on Neurospora crassa chromosome 3, encodes eukaryotic release factor 1, a protein with translation release factor activity, peptidyl-tRNA hydrolase activity, GTPase regulator activity and sequence-specific mRNA binding. The gene is associated with cytoplasmic translational termination, translational readthrough, nonsense-mediated mRNA decay, sno(s)RNA transcription and DNA-templated transcription termination. It localises to the translation release factor complex, cytoplasm, cytosol and stress granules. NcERF1 is associated with abnormal filamentous growth, increased alkaline pH resistance, increased desiccation resistance, increased starvation resistance, increased vegetative growth rate, abnormal cell wall morphology, increased autophagy, increased mating response, and absent anaerobic growth, endocytosis, adhesion, cytokinesis and cell death.