GTR2 — Neurospora crassa

Summary

NCU00376 (GTR2) in Neurospora crassa encodes a GTP-binding protein of the RagC/D and Gtr1_RagA family, with GTPase activity and GTP binding, and is annotated with protein serine/threonine kinase activator activity. It is a component of the Gtr1-Gtr2 GTPase complex and localizes to the endomembrane system, fungal-type vacuole membrane, cytosol, and nucleus. The gene is associated with negative regulation of autophagy, upregulation of TORC1 signaling, negative regulation of mitotic-to-meiotic cell cycle switching, cellular response to starvation, and spore formation. Phenotypic associations include increased cell death, absent vacuolar morphology, abnormal replicative lifespan, absent meiosis, increased hydrostatic pressure and X-ray resistance, altered nutrient uptake, decreased fermentative and respiratory metabolism, and increased entry into G0 stationary phase. Studies of related genes in other species link the family to acid sensitivity and oxidative stress response.