ALD2 — Neurospora crassa

Summary

NCU00378 (ALD2) on Neurospora crassa chromosome 3 encodes a betaine-aldehyde dehydrogenase (NAD+) with aldehyde dehydrogenase [NAD(P)+] and acetaldehyde dehydrogenase (NAD+) activities, classified as EC 1.2.1.3. The protein contains aldehyde dehydrogenase domains and is localized to mitochondria, cytoplasm, cytosol, nucleus, Golgi complex, and extracellular space. ALD2 is associated with response to furfural, carbon catabolite activation of transcription, cellular detoxification of aldehydes and nitrogen compounds, polyamine and threonine breakdown, ethanol and acetaldehyde metabolism, acetate anabolism, fermentation, spore germination, meiotic cell cycle, and osmotic response. Phenotypic associations include increased adhesive and filamentous growth, decreased fermentative and respiratory metabolism, altered cell cycle progression, increased thermotolerance and replicative lifespan, decreased UV resistance and osmotic stress resistance, and abnormal colony and actin morphology.