BRLA — Neurospora crassa

Summary

NCU00340 (BRLA, also known as pp-1) on Neurospora crassa chromosome 3 encodes a STE12 transcription factor containing C2H2-type zinc finger domains and exhibits sequence-specific DNA-binding and RNA polymerase II transcription factor activity. This gene is associated with mating behavior, chemotropism, fruiting body formation, sexual reproduction, and regulation of filamentous and pseudohyphal growth. It is linked to carbon catabolite repression, galactose metabolism, cellular response to nutrient, tube formation, and biofilm formation regulation. Phenotypic associations include abnormal biofilm formation, increased pheromone production, absent mating efficiency, abnormal carbon source utilization, and increased polyploidy rate. The encoded protein localizes to the nucleus, cytoplasm, membrane, chromatin, and Tec1p-Ste12p-Dig1p complex. Related genes in other species link the STE12 family to sporogenesis, germination rate, oxidative stress response, and virulence.