TIM23 — Neurospora crassa

Summary

NCU00371 (TIM23) in Neurospora crassa encodes a Tim23-like protein that localises to mitochondria and has mitochondrion targeting sequence binding and transmembrane protein transporter activity. The gene is associated with mitochondrial protein import, including import into the matrix, intracellular protein transport, and structural organisation. Phenotypic associations link TIM23 to a wide range of processes: absent or decreased mitochondrial transport, absent respiratory metabolism, anaerobic growth, spore germination, and protein activity, alongside increased cell death, petite frequency, and desiccation resistance. Abnormalities in cell cycle progression, redox state, mitochondrial distribution and genome maintenance, peroxisomal morphology, and increased lifespan are also connected. The gene is further associated with the Tim23 complex and related mitochondrial import machinery.