TRP1 — Neurospora crassa

Summary

NCU00200, also known as TRP1 on Neurospora crassa chromosome 3, encodes a protein with anthranilate synthase, phosphoribosylanthranilate isomerase, and indole-3-glycerol-phosphate synthase activities (EC 4.1.1.48, 5.3.1.24, 4.1.3.27). The gene is associated with tryptophan formation, indole anabolism, and amino acid anabolism, as well as aerial mycelium formation, catabolite repression, and translation initiation. The product localizes to the cytosol as part of the anthranilate synthase complex. TRP1 is linked to numerous phenotypes including decreased resistance to gamma rays, UV, ionic stress, and freeze-thaw conditions, increased chronological lifespan, abnormal cell cycle progression, reduced filamentous growth and sporulation, and altered stress resistance. Studies of related genes in other species connect the family to oxidative stress response and nitrogen utilization.