PKU80 — Neurospora crassa

Summary

NCU00077 (symbol PKU80, also known as mus-52) in Neurospora crassa chromosome 3 encodes the Ku80 protein, a subunit of the Ku70:Ku80 complex. The product possesses ATP-dependent 3'-5' DNA helicase activity (EC 3.6.4.12), binds damaged DNA, double-stranded DNA, and telomeric repeats, and localises to the nucleus, cytosol, and chromosome telomeric regions. The gene is associated with non-homologous end joining (NHEJ), homologous recombination, DNA replication, DNA recombination, and telomere maintenance.