PACC — Neurospora crassa

Summary

NCU00090 (PACC, also known as RIM101 or NcPACC) on Neurospora crassa chromosome 3 encodes a zinc-finger C2H2 protein of the pacC/RIM101 family. The product binds DNA and zinc, and is associated with the cellular response to basic pH, regulation of gene expression, signal transduction, mating, secretion, membrane transport, chromatin remodeling, autophagy, homeostasis, cell growth, cell cycle, and glycogen metabolism. It localises to both the cytoplasm and nucleus. Studies of related genes in other species link the family to pH response, sugar content, and altered virulence, including hypervirulence and reduced virulence, as well as associations with plant pathogens causing white mold, stem rot, vascular wilt, and rice blast.