ATP6 — Neurospora crassa

Summary

NCU16025 (NcATP6, ATP6) on the Neurospora crassa mitochondrial chromosome encodes the ATP synthase F0 subunit a, a component of the proton-transporting ATP synthase complex. The gene product possesses proton transporter activity and is localized to the mitochondrial inner membrane as part of the F1-F0 complex. It is associated with proton motive force-driven ATP synthesis, mitochondrial transcription, RNA splicing, and spore germination. Phenotypic associations link ATP6 to decreased respiratory metabolism and growth, increased mitochondrial rho- mutation frequency, abnormal mitochondrial genome maintenance, altered apoptosis, defective sporulation, increased cell size, decreased autophagy, and increased stress resistance and innate thermotolerance. The gene is also connected to altered carbon source utilization, lipid particle morphology, and cell cycle progression. Studies of related genes in other species link the family to respiratory growth and chemical resistance.