COX1 — Neurospora crassa

Summary

NCU16016 (NcCOX1) on the Neurospora crassa mitochondrial chromosome encodes cytochrome c oxidase subunit 1, a core component of respiratory chain complex IV. The gene product possesses cytochrome-c oxidase activity, heme binding, and metal binding, and is localised to the mitochondrial inner membrane. It is associated with aerobic respiration, electron transport coupled proton transport, mitochondrial electron transport from cytochrome c to oxygen, and oxidative phosphorylation. This gene is linked to numerous phenotypes including absent respiratory metabolism, decreased mitochondrial transport, increased mutation frequency, abnormal cytokinesis, increased mitophagy, and altered nitrogen source utilisation. Related genes in other species connect the family to oxidative stress response.