EGT2 — Neurospora crassa

Summary

NCU11365 (EGT2, NcEGT2) on Neurospora crassa chromosome 4 encodes a pyridoxal phosphate-dependent aminotransferase-class V domain protein with hercynylcysteine sulfoxide lyase activity (ergothioneine-forming), classified as EC 4.4.1.36. This gene is associated with ergothioneine and selenoneine biosynthesis, alkaloid metabolism, amino acid biosynthesis, and fermentation. The encoded product localizes to the cytoplasm, cytosol, and nucleus. Related genes in other species link the EGT2 family to aminotransferase activity and to plant pathogens including Verticillium dahliae, Fusarium oxysporum f. sp. cubense TR4, and Fusarium oxysporum f. sp. lycopersici.